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“Jeopardy!” host Alex Trebek says that he is undergoing another round of chemotherapy.

In an interview with “GMA,” Trebek told ABC News' T.J. Holmes that his doctors have decided to have him undergo chemo again after he lost a large amount of weight and his numbers sky rocketed right after finishing his first round of treatment for stage 4 pancreatic cancer.

“I was doing so well. And my numbers went down to the equivalent of a normal human being who does not have pancreatic cancer. So we were all very optimistic. And they said, 'Good, we're gonna stop chemo, we'll start you on immunotherapy,'" he said before, "I lost about 12 pounds in a week. And my numbers went sky high, much higher than they were when I was first diagnosed. So, the doctors have decided that I have to undergo chemo again and that's what I'm doing."

Trebek talked about how cancer has taken a toll on his body saying sometimes it’s “excruciating pain” and other times “fatigue.”

“Cancer is mysterious in more ways than one,” he said.

The game show host also revealed his battle with depression that started when he was first diagnosed saying that sometimes he feels a “surge of sadness” and “depression.”

“When it happened early on I was down on myself,” he told “GMA.” “I didn’t realize how fallible each of us is in his or her own way … I talk to the audience sometimes and I get teary eyed for no reason. I don’t even bother to explain it anymore, I just experience it. I know it's a part of who I am and I just keep going.”