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Sen. Roy Blunt of Missouri announced on Monday that he will not run for reelection in 2022, a surprise decision from the No. 4 GOP leader that comes amid a slew of retirements from top Senate Republicans.

Blunt, who was first elected to the Senate in 2010 and previously served for 14 years in the House, is the fifth Republican this cycle to announce his retirement. His decision is certain to set off a messy GOP primary in a state where former President Donald Trump remains popular.