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Reversing age-related cognitive impairments
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wtg
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posted 07 December 2020 09:22 AM
Just in mice so far, but interesting nonetheless.

quote:
Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists.

The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer and even enhance cognition in healthy animals.

In the new study, published Dec. 1, 2020, in the open-access journal eLife, researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.

“ISRIB’s extremely rapid effects show for the first time that a significant component of age-related cognitive losses may be caused by a kind of reversible physiological ‘blockage’ rather than more permanent degradation,” said Susanna Rosi, Ph.D., Lewis and Ruth Cozen Chair II and professor in the departments of Neurological Surgery and of Physical Therapy and Rehabilitation Science.

“The data suggest that the aged brain has not permanently lost essential cognitive capacities, as was commonly assumed, but rather that these cognitive resources are still there but have been somehow blocked, trapped by a vicious cycle of cellular stress,” added Peter Walter, Ph.D., a professor in the UCSF Department of Biochemistry and Biophysics and a Howard Hughes Medical Institute investigator. “Our work with ISRIB demonstrates a way to break that cycle and restore cognitive abilities that had become walled off over time.”


https://www.universityofcalifo...-decline-within-days


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ShiroKuro
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posted 07 December 2020 09:58 AMHide Post
quote:
The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer and even enhance cognition in healthy animals.


Wow, that's quite a list!


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wtg
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posted 07 December 2020 10:19 AMHide Post
It does seem pretty far reaching (or maybe far fetched!), but sometimes there's an common element underlying various conditions that can explain things.

I'm going to send the university's press release to my friend who is a medical researcher. Part of her research involves examining changes in the eye that result from traumatic brain injury. She has been studying TBI for some time and may have some insights.


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Amanda
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posted 07 December 2020 10:31 AMHide Post
WOW!! That pretty much runs the gamut, except restoring erectile dysfunction. Eeker


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wtg
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posted 07 December 2020 10:36 AMHide Post
Yea, I'd be kind of writing it off but Peter Walter has received the Lasker Award along with a bunch of other awards.

http://www.laskerfoundation.or...ed-protein-response/

A lot of Lasker winners go on to win the Nobel Prize....


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wtg
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posted 07 December 2020 12:43 PMHide Post
My friend's response to my query about the research..

quote:
It passes the sniff test, with a few caveats:

1) the work was funded by NIH (there was a smiley here)

2) the author whose lab the work was performed in won the Lasker Award, which is considered the last step on the way to a nobel prize

3) eLife is a new journal, whose stated purpose is to publish good papers before review. They only accept 15% of submissions, and say they are in competition with Nature and Science. But their impact factor is much lower than those journals, so they spend a lot of time arguing how the impact factor (determined by # of citations their papers receive) is unimportant. I'm surprised they didn't submit work of this magnitude to Science or Nature.

4) Mice are way different than humans and even rats, and a number of successful preclinical trials run with mice were completely unsuccessful in humans. Why didn't they use rats? (there was another smiley here)




(Bias alert....my friend works with rats in her research....)


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Piano*Dad
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posted 07 December 2020 02:06 PMHide Post
quote:
Originally posted by Amanda:
WOW!! That pretty much runs the gamut, except restoring erectile dysfunction. Eeker


Big Grin

who knows ...
 
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Piano*Dad
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posted 07 December 2020 02:08 PMHide Post
And on the Vision Front ...

Perhaps we can tackle age-related vision loss.

Personal stake in this one!

Alas, .... mice again. Razzer
 
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wtg
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posted 07 December 2020 03:24 PMHide Post
Sent that to my friend. She said "great article. why'd they use mice?"

Big Grin


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CHAS
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posted 07 December 2020 03:24 PMHide Post
Tell them to hurry. I forget why.


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Jack Frost
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posted 07 December 2020 03:29 PMHide Post
quote:
Originally posted by Piano*Dad:
quote:
Originally posted by Amanda:
WOW!! That pretty much runs the gamut, except restoring erectile dysfunction. Eeker


Big Grin

who knows ...


Who would want to restore erectile dysfunction?


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Mikhailoh
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posted 07 December 2020 06:29 PMHide Post
Maybe. you'd have to see the spouse involved.


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Steve Miller
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posted 07 December 2020 07:09 PMHide Post
quote:
Originally posted by CHAS:
Tell them to hurry. I forget why.


Smiler Smiler Smiler


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CHAS
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posted 08 December 2020 08:09 AMHide Post
quote:
Originally posted by Jack Frost:
quote:
Originally posted by Piano*Dad:
quote:
Originally posted by Amanda:
WOW!! That pretty much runs the gamut, except restoring erectile dysfunction. Eeker


Big Grin

who knows ...


Who would want to restore erectile dysfunction?


hysteric


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AdagioM
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posted 08 December 2020 01:32 PMHide Post
quote:
Originally posted by CHAS:
quote:
Originally posted by Jack Frost:
quote:
Originally posted by Piano*Dad:
quote:
Originally posted by Amanda:
WOW!! That pretty much runs the gamut, except restoring erectile dysfunction. Eeker


Big Grin

who knows ...


Who would want to restore erectile dysfunction?


hysteric


Sale on saltpeter!


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