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White House Chief of Staff Mark Meadows on Friday told Stephen Hahn, the commissioner of the Food and Drug Administration, to submit his resignation if the agency does not clear the nation’s first coronavirus vaccine by day’s end, according to people familiar with the situation who spoke on the condition of anonymity because they were not authorized to discuss what happened.

The threat came on the same day that President Trump tweeted that the FDA is “a big, old, slow turtle” in its handling of vaccines, while exhorting Commissioner Stephen Hahn to “get the dam vaccines out NOW.” He added: “Stop playing games and start saving lives!!!”

It also led the FDA to accelerate its timetable for clearing America’s first vaccine from Saturday morning to later Friday, according to two people familiar with the process who spoke on the condition of anonymity to discuss internal matters.

The White House actions once again inject politics into the vaccine race, potentially undermining public trust in one of the most crucial tools to end the pandemic that has killed more than 290,000 Americans. It comes in the midst of a process that had been designed to show no shortcuts were taken in reviewing the safety and effectiveness of a vaccine as surveys show many people remain unsure whether they will get the shots.

A White House official declined to comment, saying “we don’t comment on private conversations, but the Chief regularly requests updates on progress toward a vaccine.”

“This is an untrue representation of the phone call with the Chief of Staff,” Hahn said in a statement. “The FDA was encouraged to continue working expeditiously on Pfizer-BioNTech’s EUA request. FDA is committed to issuing this authorization quickly, as we noted in our statement this morning.”