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Jeffrey E. Epstein, a billionaire New York financier long accused of molesting dozens of young girls, has been charged by federal prosecutors with sex trafficking, two people with knowledge of the case said on Saturday night.

Mr. Epstein was arrested in the New York area and is in federal custody. He is expected to appear before a federal magistrate on Monday.

Mr. Epstein had avoided federal criminal charges in 2007 and 2008 in a widely criticized plea deal after he was accused of paying dozens of underage girls for sexual massages in Florida.

Before then, Mr. Epstein, a former hedge-fund manager, had been friendly with Donald J. Trump, former President Bill Clinton and Prince Andrew, the Duke of York.

He pleaded guilty to lesser state charges of soliciting prostitution, served 13 months in a county lockup and registered as a sex offender. His extraordinary jail arrangement allowed him to get out of the Palm Beach County Stockade six days a week to work out of his office.

The United States attorney’s office in Manhattan, which brought the charges against Mr. Epstein, declined to comment on Saturday night.

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Miami Herald investigative reporter Julie K. Brown, who has done original reporting on details of the alleged sex trafficking crimes of billionaire Jeffrey Epstein for the past several years, joined MSNBC Sunday morning to discuss the evidence against Epstein and the "rogues gallery" of rich, powerful, and famous people who are suspected to have used his services. Epstein was arrested Saturday in New Jersey on sex trafficking charges.

"I've felt a lot of pressure," Brown said. "Needless to say, these are very powerful people and I think that they're sweating a little bit, especially today. We don't know how much, how deep this went, how far-reaching it went in government, but there have been a lot of names that I could see on these message pads [listing clients] on a regular basis as part of the evidence. These message pads where they would call and leave Epstein messages, such as, 'I'm at this hotel.' Why do you do that, unless you're expecting him to send you a girl to visit you at your hotel? So there are probably quite a few important people, powerful people, who are sweating it out right now. We'll have to wait and see whether Epstein is going to name names."

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Jeffrey Epstein, the financier facing sex-trafficking charges in New York, tried to influence possible witnesses against him, prosecutors said on Friday, wiring $350,000 to two people who might testify against him at trial.

Mr. Epstein sent the money to the potential witnesses in late November and early December, 2018, shortly after the Miami Herald began publishing an investigative report about a secret deal he had reached with the authorities in Florida to avoid federal prosecution, prosecutors said.

The United States attorney’s office in Manhattan made the new allegations in a court filing asking that Mr. Epstein be denied bail while he awaits trial, saying the payments were evidence that he might try to influence witnesses if he were not detained.

The prosecutors have not charged Mr. Epstein in connection with the new allegations, and a spokesman for the United States attorney’s office declined to comment on that possibility.

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Mr. Epstein’s lawyers maintain their client has lived a law-abiding life for the past 14 years, since he pleaded guilty to state prostitution charges in Florida and served 13 months in jail. He has plead not guilty to the new federal indictment in Manhattan.

Prosecutors said Mr. Epstein had paid significant amounts of money to influence individuals who were close to him and “who might be witnesses against him at a trial,” the government’s filing said.

Two days after the Herald published its expose, Mr. Epstein wired $100,000 to a person who had been named as a possible co-conspirator in his deal with Florida prosecutors a decade ago.

Three days later, Mr. Epstein sent $250,000 to a person who not only had been named as a co-conspirator in the Florida agreement, but was also identified in the New York indictment as an employee who helped Mr. Epstein in his sex-trafficking scheme.

The payments and their timing, the prosecutors wrote, “suggests the defendant was attempting to further influence co-conspirators who might provide information against him in light of the recently emerging allegations.”